Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
- PMID: 22033522
- DOI: 10.1126/science.1211878
Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission
Abstract
In sexual reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized. Paternal mitochondria and their genomes are generally eliminated in the embryo by an unknown degradation mechanism. We show that, upon fertilization, a Caenorhabditis elegans spermatozoon triggers the recruitment of autophagosomes within minutes and subsequent paternal mitochondria degradation. Whereas the nematode-specific sperm membranous organelles are ubiquitinated before autophagosome formation, the mitochondria are not. The degradation of both paternal structures and mitochondrial DNA requires an LC3-dependent autophagy. Analysis of fertilized mouse embryos shows the localization of autophagy markers, which suggests that this autophagy event is evolutionarily conserved to prevent both the transmission of paternal mitochondrial DNA to the offspring and the establishment of heteroplasmy.
Comment in
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Development: autophagy eliminates paternal mitochondria.Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):771. doi: 10.1038/nrm3234. Nat Rev Mol Cell Biol. 2011. PMID: 22086368 No abstract available.
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Development. Inheriting maternal mtDNA.Science. 2011 Nov 25;334(6059):1069-70. doi: 10.1126/science.1215480. Science. 2011. PMID: 22116870 Free PMC article. No abstract available.
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Re: Postfertilization autophagy of the sperm organelles prevents paternal mitochondrial DNA transmission.Eur Urol. 2012 Mar;61(3):625-6. doi: 10.1016/j.eururo.2011.12.041. Eur Urol. 2012. PMID: 22289978 No abstract available.
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