AMPK and mTOR in cellular energy homeostasis and drug targets
- PMID: 22017684
- DOI: 10.1146/annurev-pharmtox-010611-134537
AMPK and mTOR in cellular energy homeostasis and drug targets
Abstract
The mammalian target of rapamycin (mTOR) is a central controller of cell growth and proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 is regulated by multiple signals such as growth factors, amino acids, and cellular energy and regulates numerous essential cellular processes including translation, transcription, and autophagy. The AMP-activated protein kinase (AMPK) is a cellular energy sensor and signal transducer that is regulated by a wide array of metabolic stresses. These two pathways serve as a signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth, and dysregulation of each pathway may contribute to the development of metabolic disorders such as obesity, type 2 diabetes, and cancer. This review focuses on our current understanding of the relationship between AMPK and mTORC1 signaling and discusses their roles in cellular and organismal energy homeostasis.
Similar articles
-
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.Acta Physiol (Oxf). 2009 May;196(1):65-80. doi: 10.1111/j.1748-1716.2009.01972.x. Epub 2009 Feb 19. Acta Physiol (Oxf). 2009. PMID: 19245654 Free PMC article. Review.
-
Spatial regulation of the mTORC1 system in amino acids sensing pathway.Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):671-9. doi: 10.1093/abbs/gmr066. Epub 2011 Jul 23. Acta Biochim Biophys Sin (Shanghai). 2011. PMID: 21785113 Free PMC article. Review.
-
Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.PLoS One. 2015 Mar 11;10(3):e0116550. doi: 10.1371/journal.pone.0116550. eCollection 2015. PLoS One. 2015. PMID: 25761126 Free PMC article.
-
Antagonistic control of muscle cell size by AMPK and mTORC1.Cell Cycle. 2011 Aug 15;10(16):2640-6. doi: 10.4161/cc.10.16.17102. Epub 2011 Aug 15. Cell Cycle. 2011. PMID: 21799304
-
cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6. Cell Signal. 2011. PMID: 21763421 Free PMC article.
Cited by
-
SAD-A potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like peptide 1 response in pancreatic β cells.Mol Cell Biol. 2013 Jul;33(13):2527-34. doi: 10.1128/MCB.00285-13. Epub 2013 Apr 29. Mol Cell Biol. 2013. PMID: 23629625 Free PMC article.
-
The Novel Angiotensin-(1-7) Analog, A-1317, Improves Insulin Resistance by Restoring Pancreatic β-Cell Functionality in Rats With Metabolic Syndrome.Front Pharmacol. 2020 Aug 24;11:1263. doi: 10.3389/fphar.2020.01263. eCollection 2020. Front Pharmacol. 2020. PMID: 32982727 Free PMC article.
-
The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease.Front Endocrinol (Lausanne). 2024 Aug 8;15:1374644. doi: 10.3389/fendo.2024.1374644. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39175576 Free PMC article. Review.
-
PAS kinase: integrating nutrient sensing with nutrient partitioning.Semin Cell Dev Biol. 2012 Aug;23(6):626-30. doi: 10.1016/j.semcdb.2011.12.007. Epub 2012 Jan 8. Semin Cell Dev Biol. 2012. PMID: 22245833 Free PMC article. Review.
-
STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway.J Gastrointest Oncol. 2022 Oct;13(5):2458-2471. doi: 10.21037/jgo-22-957. J Gastrointest Oncol. 2022. PMID: 36388670 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
