On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules
- PMID: 2199576
On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules
Abstract
Species restrictions in immune cell interactions have been demonstrated both in Ag-specific responses of T lymphocytes and the phenomenon of natural attachment. To determine the possible contribution of adhesion receptors to these restrictions, we have studied binding between the murine and human homologues of LFA-1 (CD11a/CD18) and ICAM employing purified human LFA-1 and ICAM-1 (CD54) bound to solid substrates. Murine cell lines bind to purified human LFA-1 through ICAM-1 and at least one other counter-receptor. This provides evidence for multiple counter-receptors for LFA-1 in the mouse as well as in the human. In contrast to binding of murine ICAM-1 to human LFA-1, murine LFA-1 does not bind to human ICAM-1. The species specificity maps to the LFA-1 alpha subunit, because mouse x human hybrid cells expressing the human alpha subunit associated with a mouse beta subunit bind to human ICAM-1, whereas those with a human beta subunit associated with a murine alpha subunit do not. Increased adhesiveness for ICAM-1 stimulated by phorbol esters could be demonstrated for hybrid LFA-1 molecules with human alpha and murine beta subunits.
Similar articles
-
Only dull CD3+ thymocytes bind to thymic epithelial cells. The binding is elicited by both CD2/LFA-3 and LFA-1/ICAM-1 interactions.Eur J Immunol. 1989 Sep;19(9):1631-5. doi: 10.1002/eji.1830190917. Eur J Immunol. 1989. PMID: 2477252
-
Clonal heterogeneity in LFA-3 and ICAM-1 requirement for lysis by alloreactive T lymphocytes.J Immunol. 1993 Mar 1;150(5):1653-62. J Immunol. 1993. PMID: 7679690
-
Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off.Immunology. 1995 Nov;86(3):408-15. Immunology. 1995. PMID: 8550078 Free PMC article.
-
On the mode of action of LFA-1.Immunol Today. 1990 Aug;11(8):277-80. doi: 10.1016/0167-5699(90)90112-m. Immunol Today. 1990. PMID: 2144966 Review. No abstract available.
-
Role of LFA-1 and ICAM-1 in Cancer.Cancers (Basel). 2017 Nov 3;9(11):153. doi: 10.3390/cancers9110153. Cancers (Basel). 2017. PMID: 29099772 Free PMC article. Review.
Cited by
-
Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?J Neuroimmune Pharmacol. 2012 Jun;7(2):352-62. doi: 10.1007/s11481-011-9335-y. Epub 2012 Jan 7. J Neuroimmune Pharmacol. 2012. PMID: 22222956 Free PMC article. Review.
-
Thalidomide derivatives and the immune system. I. Changes in the pattern of integrin receptors and other surface markers on T lymphocyte subpopulations of marmoset blood.Arch Toxicol. 1993;67(1):1-17. doi: 10.1007/BF02072029. Arch Toxicol. 1993. PMID: 8452474
-
Supported Lipid Bilayer Technology for the Study of Cellular Interfaces.Curr Protoc Cell Biol. 2015 Sep 1;68:24.5.1-24.5.31. doi: 10.1002/0471143030.cb2405s68. Curr Protoc Cell Biol. 2015. PMID: 26331983 Free PMC article.
-
CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus.Cancers (Basel). 2021 Mar 2;13(5):1050. doi: 10.3390/cancers13051050. Cancers (Basel). 2021. PMID: 33801448 Free PMC article.
-
Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7993-7. doi: 10.1073/pnas.88.18.7993. Proc Natl Acad Sci U S A. 1991. PMID: 1716769 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources
Miscellaneous