Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys
- PMID: 21889587
- DOI: 10.1016/j.reprotox.2011.07.002
Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys
Abstract
Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0-5.8). A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K(+)PFOS. Animals were followed for up to 23 weeks, and pharmacokinetic parameters were determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFOS than monkeys. The serum elimination half-lives in the rodent species were on the order of 1-2 months; whereas, in monkeys, the serum elimination half lives approximated 4 months. Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of body burden in humans on repeated exposure to PFOS and PFOS-generating materials.
Copyright © 2011 Elsevier Inc. All rights reserved.
Similar articles
-
Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys.Reprod Toxicol. 2012 Jul;33(4):441-451. doi: 10.1016/j.reprotox.2011.07.004. Epub 2011 Aug 11. Reprod Toxicol. 2012. PMID: 21856411
-
Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys--probing the determinants of long plasma half-lives.Toxicology. 2006 Oct 3;227(1-2):156-64. doi: 10.1016/j.tox.2006.08.004. Epub 2006 Aug 12. Toxicology. 2006. PMID: 16978759
-
A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans.Toxicology. 2009 Feb 4;256(1-2):65-74. doi: 10.1016/j.tox.2008.11.008. Epub 2008 Nov 19. Toxicology. 2009. PMID: 19059455
-
The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum.Environ Health Perspect. 2006 Nov;114(11):1776-82. doi: 10.1289/ehp.9060. Environ Health Perspect. 2006. PMID: 17107867 Free PMC article. Review.
-
PFOS or PreFOS? Are perfluorooctane sulfonate precursors (PreFOS) important determinants of human and environmental perfluorooctane sulfonate (PFOS) exposure?J Environ Monit. 2010 Nov;12(11):1979-2004. doi: 10.1039/c0em00295j. Epub 2010 Oct 13. J Environ Monit. 2010. PMID: 20944836 Review.
Cited by
-
Extracellular Vesicles altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health.Toxicol Sci. 2023 Oct 18;197(2):155-69. doi: 10.1093/toxsci/kfad108. Online ahead of print. Toxicol Sci. 2023. PMID: 37851381 Free PMC article.
-
Characterisation of perfluorooctane sulfonate (PFOS) in a terrestrial ecosystem near a fluorochemical plant in Flanders, Belgium.Environ Sci Pollut Res Int. 2014 Oct;21(20):11856-66. doi: 10.1007/s11356-013-2449-4. Epub 2014 Jan 3. Environ Sci Pollut Res Int. 2014. PMID: 24385186
-
Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications.Ann Pediatr Endocrinol Metab. 2017 Mar;22(1):6-14. doi: 10.6065/apem.2017.22.1.6. Epub 2017 Mar 31. Ann Pediatr Endocrinol Metab. 2017. PMID: 28443254 Free PMC article. Review.
-
Analysis of PFAAs in American alligators part 1: Concentrations in alligators harvested for consumption during South Carolina public hunts.J Environ Sci (China). 2017 Nov;61:24-30. doi: 10.1016/j.jes.2017.05.045. Epub 2017 Jun 20. J Environ Sci (China). 2017. PMID: 29191311 Free PMC article.
-
Risk to human health related to the presence of perfluoroalkyl substances in food.EFSA J. 2020 Sep 17;18(9):e06223. doi: 10.2903/j.efsa.2020.6223. eCollection 2020 Sep. EFSA J. 2020. PMID: 32994824 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
