doi: 10.1021/ol202116k.
Epub 2011 Sep 2.
Enantioselective total synthesis of the potent anti-HIV nucleoside EFdA
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- PMID: 21888325
- DOI: 10.1021/ol202116k
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Enantioselective total synthesis of the potent anti-HIV nucleoside EFdA
Org Lett.
.
Abstract
A concise enantioselective total synthesis of 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), an extremely potent anti-HIV agent, has been accomplished from (R)-glyceraldehyde acetonide in 18% overall yield by a 12-step sequence involving a highly diastereoselective ethynylation of an α-alkoxy ketone intermediate.
© 2011 American Chemical Society
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