CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis

doi:10.1016/j.ydbio.2011.08.009

. 2011 Nov 1;359(1):37-46.

doi: 10.1016/j.ydbio.2011.08.009. Epub 2011 Aug 22.

CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis

Anne Galy¹, Annette Schenck², H Bahar Sahin³, Abrar Qurashi⁴, José-Alain Sahel⁵, Céline Diebold⁶, Angela Giangrande⁷

Affiliations

¹ Fovea-Pharmaceuticals, Institut de la vision, 17 rue Moreau 75012 Paris, France.
² Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Donders Institute for Brain, Cognition and Behaviour & Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands. Electronic address: A.Schenck@antrg.umcn.nl.
³ Department of Molecular Biology and Genetics, Bogazici University, Bebek, Istanbul, Turkey.
⁴ Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
⁵ INSERM, U968, Université Pierre et Marie Curie-Paris 6, UM80, Institut de la Vision, CNRS, UMR-7210, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; Institute of Ophthalmology, University College of London, London, United Kingdom.
⁶ Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UDS, BP 10142, 67404 Illkirch, CU de Strasbourg, France.
⁷ Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UDS, BP 10142, 67404 Illkirch, CU de Strasbourg, France. Electronic address: angela@igbmc.fr.

PMID: 21884694
DOI: 10.1016/j.ydbio.2011.08.009

Free article

CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis

Anne Galy et al. Dev Biol. 2011.

Free article

. 2011 Nov 1;359(1):37-46.

doi: 10.1016/j.ydbio.2011.08.009. Epub 2011 Aug 22.

Authors

Anne Galy¹, Annette Schenck², H Bahar Sahin³, Abrar Qurashi⁴, José-Alain Sahel⁵, Céline Diebold⁶, Angela Giangrande⁷

Affiliations

¹ Fovea-Pharmaceuticals, Institut de la vision, 17 rue Moreau 75012 Paris, France.
² Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Donders Institute for Brain, Cognition and Behaviour & Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, The Netherlands. Electronic address: A.Schenck@antrg.umcn.nl.
³ Department of Molecular Biology and Genetics, Bogazici University, Bebek, Istanbul, Turkey.
⁴ Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
⁵ INSERM, U968, Université Pierre et Marie Curie-Paris 6, UM80, Institut de la Vision, CNRS, UMR-7210, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; Institute of Ophthalmology, University College of London, London, United Kingdom.
⁶ Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UDS, BP 10142, 67404 Illkirch, CU de Strasbourg, France.
⁷ Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/UDS, BP 10142, 67404 Illkirch, CU de Strasbourg, France. Electronic address: angela@igbmc.fr.

PMID: 21884694
DOI: 10.1016/j.ydbio.2011.08.009

Abstract

Cell rearrangements shape organs and organisms using molecular pathways and cellular processes that are still poorly understood. Here we investigate the role of the Actin cytoskeleton in the formation of the Drosophila compound eye, which requires extensive remodeling and coordination between different cell types. We show that CYFIP/Sra-1, a member of the WAVE/SCAR complex and regulator of Actin remodeling, controls specific aspects of eye architecture: rhabdomere extension, rhabdomere terminal web organization, adherens junctions, retina depth and basement membrane integrity. We demonstrate that some phenotypes manifest independently, due to defects in different cell types. Mutations in WAVE/SCAR and in ARP2/3 complex subunits but not in WASP, another major regulator of Actin nucleation, phenocopy CYFIP defects. Thus, the CYFIP-SCAR-ARP2/3 pathway orchestrates specific tissue remodeling processes.

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CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis

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CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis

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