Review
doi: 10.1007/978-1-4419-5632-3_10.
Impact of differential glycosylation on IgG activity
- PMID: 21842369
- DOI: 10.1007/978-1-4419-5632-3_10
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Review
Impact of differential glycosylation on IgG activity
Adv Exp Med Biol.
2011.
Abstract
Immunoglobulin G (IgG) molecules are glycoproteins with dual functionality. While participating in the destruction of virally infected cells or healthy tissues during autoimmune disease, IgG antibodies are also used as a therapeutic agent to suppress IgG-triggered autoimmune disease and inflammation. Research of recent years has put the IgG-associated sugar moiety in the spotlight for regulating these opposing activities. This review will focus on how certain IgG glycovariants impact different IgG-dependent effector functions and how this knowledge might be used to further improve the therapeutic effectiveness of this class of molecules.
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