Binary function of mRNA
- PMID: 21784124
- DOI: 10.1016/j.biochi.2011.07.008
Binary function of mRNA
Abstract
Since the discovery of messenger RNA (mRNA) over half a century ago, the assumption has always been that the only function of mRNA is to make a protein. However, recent studies of prokaryotic and eukaryotic organisms unexpectedly show that some mRNAs may be functionally binary and have additional structural functions that are unrelated to their translation product. These findings imply that some of the phenotypic features of cells and organisms can also be binary, that is, they depend both on the function of a protein and the independent structural function of its mRNA. In this review, we will discuss this concept within the framework of multifunctional RNA molecules and the RNA World Hypothesis.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Similar articles
-
Structural messenger RNA contains cytokeratin polymerization and depolymerization signals.Cell Tissue Res. 2011 Nov;346(2):209-22. doi: 10.1007/s00441-011-1255-x. Epub 2011 Oct 11. Cell Tissue Res. 2011. PMID: 21987223
-
Status of RNAs, localized in Xenopus laevis oocytes, in the frogs Rana pipiens and Eleutherodactylus coqui.J Exp Zool B Mol Dev Evol. 2005 Jan 15;304(1):28-39. doi: 10.1002/jez.b.21020. J Exp Zool B Mol Dev Evol. 2005. PMID: 15515051
-
When one is better than two: RNA with dual functions.Biochimie. 2011 Apr;93(4):633-44. doi: 10.1016/j.biochi.2010.11.004. Epub 2010 Nov 24. Biochimie. 2011. PMID: 21111023 Review.
-
RNA of AmVegT, the axolotl orthologue of the Xenopus meso-endodermal determinant, is not localized in the oocyte.Gene Expr Patterns. 2007 Jan;7(1-2):197-201. doi: 10.1016/j.modgep.2006.07.003. Epub 2006 Jul 16. Gene Expr Patterns. 2007. PMID: 16920404
-
East of EDEN was a poly(A) tail.Biol Cell. 2003 May-Jun;95(3-4):211-9. doi: 10.1016/s0248-4900(03)00038-8. Biol Cell. 2003. PMID: 12867084 Review.
Cited by
-
Multiple information carried by RNAs: total eclipse or a light at the end of the tunnel?RNA Biol. 2020 Dec;17(12):1707-1720. doi: 10.1080/15476286.2020.1783868. Epub 2020 Jun 26. RNA Biol. 2020. PMID: 32559119 Free PMC article. Review.
-
The KLF16/MYC feedback loop is a therapeutic target in bladder cancer.J Exp Clin Cancer Res. 2024 Nov 18;43(1):303. doi: 10.1186/s13046-024-03224-3. J Exp Clin Cancer Res. 2024. PMID: 39551759 Free PMC article.
-
Molecular insights into intracellular RNA localization.Int Rev Cell Mol Biol. 2013;302:1-39. doi: 10.1016/B978-0-12-407699-0.00001-7. Int Rev Cell Mol Biol. 2013. PMID: 23351709 Free PMC article. Review.
-
Nuclear export of mRNA molecules studied by SPEED microscopy.Methods. 2019 Jan 15;153:46-62. doi: 10.1016/j.ymeth.2018.08.005. Epub 2018 Aug 18. Methods. 2019. PMID: 30125665 Free PMC article. Review.
-
Targeted RNA sequencing reveals the deep complexity of the human transcriptome.Nat Biotechnol. 2011 Nov 13;30(1):99-104. doi: 10.1038/nbt.2024. Nat Biotechnol. 2011. PMID: 22081020 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
