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. 2011 Dec;19(12):2404-10.
doi: 10.1038/oby.2011.234. Epub 2011 Jul 21.

Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents

Huifen Wang  1 , Lyn M Steffen, Bengt Vessby, Samar Basu, Julia Steinberger, Antoinette Moran, David R Jacobs Jr, Ching-Ping Hong, Alan R Sinaiko
Affiliations

Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents

Huifen Wang et al. Obesity (Silver Spring). 2011 Dec.

Abstract

Pentadecanoic acid (15:0) and heptadecanoic acid (17:0), the dairy-specific saturated fatty acids have been inversely, while inflammation and oxidative stress have been positively related to the risk of cardiovascular disease (CVD). Both fatty acid metabolism and inflammation and oxidative stress may be influenced by adiposity. In the current cross-sectional analyses among adolescents (mean age 15 years), we determined whether overweight status modified the associations between dairy fatty acids (pentadecanoic acid (15:0) and heptadecanoic acid (17:0)) represented in serum phospholipids (PL) and markers of inflammation and oxidative stress. Six biomarkers for inflammation and oxidative stress were analyzed, including circulating adiponectin, C-reactive protein (CRP), cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and urinary 15-keto-dihydro-PGF2α (15-keto) and 8-iso-PGF2α (F2-iso). Generalized linear regression analyses, adjusted for age, gender, race, tanner score, total energy intake and physical activity, revealed that PL dairy fatty acids were inversely associated with CRP, F2-iso and 15-keto in overweight, but not in normal weight adolescents (all P(interaction) < 0.05). However, higher level of PL dairy fatty acids was associated with lower IL-6 among all adolescents. Further adjustment for dietary intake of calcium, vitamin D, protein, total flavonoids, and ω-3 fatty acids did not materially change the findings. Dairy-specific saturated fats, i.e., 15:0 and 17:0 fatty acids, may contribute to the potential health benefits of dairy products, especially for overweight adolescents.

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Conflict of interest statement

Disclosure: The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
The interactions between weight status and biomarkers of dairy fats in relation to inflammation and oxidative stress, adjusted for gender, age, ethnicity, tanner score, total calorie intake and physical activity (n = 305). (a) Association of phospholipids dairy fatty acids with C-reactive protein (CRP) among normal weight and overweight adolescents. (b) Association of phospholipids dairy fatty acids with 8-iso-PGF2α among normal weight and overweight adolescents. (c) Association of phospholipids dairy fatty acids with 15-keto-PGF2α among normal weight and overweight adolescents. Geometric mean levels for CRP and F2-isoprostanes.
Figure 2
Figure 2
The associations between biomarkers of dairy fats in serum phospholipids and inflammation, adjusted for gender, age, ethnicity, tanner score, total calorie intake and physical activity (n = 305). Geometric mean level for IL-6.
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