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Review
. 2011 Jul 19;12(8):715-23.
doi: 10.1038/ni.2060.

Inflammation meets cancer, with NF-κB as the matchmaker

Yinon Ben-Neriah  1 , Michael Karin
Affiliations
Review

Inflammation meets cancer, with NF-κB as the matchmaker

Yinon Ben-Neriah et al. Nat Immunol. .

Abstract

Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors. Understanding the activity and function of NF-κB in the context of tumorigenesis is critical for its successful taming, an important challenge for modern cancer biology.

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References

    1. Nature. 2007 Jun 21;447(7147):972-8 - PubMed
    1. Nat Med. 1996 Sep;2(9):998-1004 - PubMed
    1. Cancer Cell. 2010 May 18;17(5):481-96 - PubMed
    1. J Immunol. 1996 Jan 1;156(1):183-91 - PubMed
    1. BMC Biol. 2010 May 21;8:66 - PubMed

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