doi: 10.1016/s0006-291x(05)80875-7.
Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes
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- PMID: 2176495
- DOI: 10.1016/s0006-291x(05)80875-7
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Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes
Biochem Biophys Res Commun.
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Abstract
Non-enzymatic glycation of reactive amino groups in model proteins increased the rate of free radical production at physiologic pH by nearly fifty-fold over non-glycated protein. Superoxide generation was confirmed by electron paramagnetic resonance measurements with the spin-trap phenyl-t-butyl-nitrone. Both Schiff base and Amadori glycation products were found to generate free radicals in a ratio of 1:1.5. Free radicals generated by glycated protein increased peroxidation of membranes of linoleic/arachidonic acid vesicles nearly 2-fold over control, suggesting that the increased glycation of proteins in diabetes may accelerate vascular wall lipid oxidative modification.
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