Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice
- PMID: 21694816
- PMCID: PMC3105633
- DOI: 10.1177/1756285611403646
Symptomatic therapy in multiple sclerosis: a review for a multimodal approach in clinical practice
Abstract
As more investigations into factors affecting the quality of life of patients with multiple sclerosis (MS) are undertaken, it is becoming increasingly apparent that certain comorbidities and associated symptoms commonly found in these patients differ in incidence, pathophysiology and other factors compared with the general population. Many of these MS-related symptoms are frequently ignored in assessments of disease status and are often not considered to be associated with the disease. Research into how such comorbidities and symptoms can be diagnosed and treated within the MS population is lacking. This information gap adds further complexity to disease management and represents an unmet need in MS, particularly as early recognition and treatment of these conditions can improve patient outcomes. In this manuscript, we sought to review the literature on the comorbidities and symptoms of MS and to summarize the evidence for treatments that have been or may be used to alleviate them.
Keywords: clinical medicine; comorbidity; multiple sclerosis; neurology; review; signs and symptoms; therapy.
Figures
![Figure 1.](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0750/3105633/eb790d1351a8/10.1177_1756285611403646-fig1.gif)
Similar articles
-
The future of Cochrane Neonatal.Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12. Early Hum Dev. 2020. PMID: 33036834
-
Comorbidity in Multiple Sclerosis.Front Neurol. 2020 Aug 21;11:851. doi: 10.3389/fneur.2020.00851. eCollection 2020. Front Neurol. 2020. PMID: 32973654 Free PMC article. Review.
-
Management of Multiple Sclerosis Symptoms and Comorbidities.Continuum (Minneap Minn). 2019 Jun;25(3):753-772. doi: 10.1212/CON.0000000000000732. Continuum (Minneap Minn). 2019. PMID: 31162315 Review.
-
Comorbidities contribute substantially to the severity of common multiple sclerosis symptoms.J Neurol. 2021 Feb;268(2):559-568. doi: 10.1007/s00415-020-10192-z. Epub 2020 Sep 2. J Neurol. 2021. PMID: 32876720
-
Advances in the management of multiple sclerosis spasticity: multiple sclerosis spasticity guidelines.Expert Rev Neurother. 2013 Dec;13(12 Suppl):55-9. doi: 10.1586/14737175.2013.865880. Expert Rev Neurother. 2013. PMID: 24289845 Review.
Cited by
-
Walking impairment in patients with multiple sclerosis - a new therapeutic approach and clinical potential of dalfampridine extended release tablets.Degener Neurol Neuromuscul Dis. 2012 Jun 22;2:53-64. doi: 10.2147/DNND.S19839. eCollection 2012. Degener Neurol Neuromuscul Dis. 2012. PMID: 30890878 Free PMC article. Review.
-
In Vivo Assessment of the Ameliorative Impact of Some Medicinal Plant Extracts on Lipopolysaccharide-Induced Multiple Sclerosis in Wistar Rats.Molecules. 2022 Feb 28;27(5):1608. doi: 10.3390/molecules27051608. Molecules. 2022. PMID: 35268709 Free PMC article.
-
Multiple sclerosis: Pathology, diagnosis and treatments.Exp Ther Med. 2017 Jun;13(6):3163-3166. doi: 10.3892/etm.2017.4410. Epub 2017 Apr 28. Exp Ther Med. 2017. PMID: 28588671 Free PMC article.
-
Ozanimod to Treat Relapsing Forms of Multiple Sclerosis: A Comprehensive Review of Disease, Drug Efficacy and Side Effects.Neurol Int. 2020 Dec 3;12(3):89-108. doi: 10.3390/neurolint12030016. Neurol Int. 2020. PMID: 33287177 Free PMC article. Review.
-
Symptomatic management in multiple sclerosis.Ann Indian Acad Neurol. 2015 Sep;18(Suppl 1):S35-42. doi: 10.4103/0972-2327.164827. Ann Indian Acad Neurol. 2015. PMID: 26538847 Free PMC article. Review.
References
-
- Abraham S., Scheinberg L.C., Smith C.R., LaRocca N.G. (1997) Neurologic impairment and disability status in outpatients with multiple sclerosis reporting dysphagia symptomatology. Neurorehabil Neural Repair 11: 7–13
-
- Albrecht H., Schwecht M., Pollmann W., Parag D., Erasmus L.P., Konig N. (1998) Local ice application in therapy of kinetic limb ataxia. Clinical assessment of positive treatment effects in patients with multiple sclerosis. Nervenarzt 69: 1066–1073 - PubMed
-
- Alusi S.H., Worthington J., Glickman S., Bain P.G. (2001) A study of tremor in multiple sclerosis. Brain 124: 720–730 - PubMed
-
- Amato M.P., Portaccio E., Goretti B., Zipoli V., Battaglini M., Bartolozzi M.L., et al. (2007) Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosis. Arch Neurol 64: 1157–1161 - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous