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Comparative Study
. 2011 Jun 12;43(7):695-8.
doi: 10.1038/ng.856.

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Daniel I Chasman  1 , Markus Schürks, Verneri Anttila, Boukje de Vries, Ulf Schminke, Lenore J Launer, Gisela M Terwindt, Arn M J M van den Maagdenberg, Konstanze Fendrich, Henry Völzke, Florian Ernst, Lyn R Griffiths, Julie E Buring, Mikko Kallela, Tobias Freilinger, Christian Kubisch, Paul M Ridker, Aarno Palotie, Michel D Ferrari, Wolfgang Hoffmann, Robert Y L Zee, Tobias Kurth
Affiliations
Comparative Study

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Daniel I Chasman et al. Nat Genet. .

Abstract

Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10(-9); rs10166942, OR = 0.85, P = 5.5 × 10(-12); and rs11172113, OR = 0.90, P = 4.3 × 10(-9)). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.

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Conflict of interest statement

Competing Financial Interests

None of the authors has a competing financial interest with regard to this manuscript.

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