Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Sep 16;585(18):2914-9.
doi: 10.1016/j.febslet.2011.05.056. Epub 2011 Jun 12.

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

Simon Bekker-Jensen  1 , Niels Mailand
Affiliations
Free article
Review

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

Simon Bekker-Jensen et al. FEBS Lett. .
Free article

Abstract

DNA double-strand breaks (DSBs) represent the most destructive type of chromosomal lesion and trigger rapid chromatin restructuring accompanied by accumulation of proteins in the vicinity of the DSB. Non-proteolytic ubiquitylation of chromatin surrounding DSBs, mediated by the RNF8/RNF168 ubiquitin ligase cascade, has emerged as a key mechanism for restoration of genome integrity by licensing the DSB-modified chromatin to concentrate genome caretaker proteins such as 53BP1 and BRCA1 near the lesions. In parallel, SUMOylation of upstream DSB regulators is also required for execution of this ubiquitin-dependent chromatin response, but its molecular basis is currently unclear. Here, we discuss recent insights into how ubiquitin- and SUMO-dependent signaling processes cooperate to orchestrate protein interactions with sites of DNA damage to facilitate DSB repair.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles