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Review
. 2011 Jun;24(2):231-56.
doi: 10.1016/j.beha.2011.03.002. Epub 2011 May 5.

Novel antibodies against follicular non-Hodgkin's lymphoma

Tom van Meerten  1 , Anton Hagenbeek
Affiliations
Review

Novel antibodies against follicular non-Hodgkin's lymphoma

Tom van Meerten et al. Best Pract Res Clin Haematol. 2011 Jun.

Abstract

The anti-CD20 monoclonal antibody rituximab has revolutionized the treatment of patients with follicular B-cell lymphoma. With the combination of chemotherapy and rituximab the overall survival rate has increased with approximately 30%. Unfortunately, there is resistance to rituximab with relapse of the disease in about 60% of the patients during the first five years of treatment and eventually in all patients. To this end, there is a need to develop improved anti-CD20 monoclonal antibodies and antibodies that target other attractive molecules expressed on the follicular lymphoma cell. This review describes the development and clinical achievements so far of next generation anti-CD20 and other antibodies in the treatment of follicular B-cell lymphoma.

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