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Review
. 2011 Jul 14;118(2):231-9.
doi: 10.1182/blood-2011-04-285981. Epub 2011 May 26.

Transcription factor networks in erythroid cell and megakaryocyte development

Louis C Doré  1 , John D Crispino
Affiliations
Review

Transcription factor networks in erythroid cell and megakaryocyte development

Louis C Doré et al. Blood. .

Abstract

Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.

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Figures

Figure 1
Figure 1
Erythroid cells and megakaryocytes are derived from a common progenitor. The decision of whether the MEP should give rise to red cell or platelet lineages is controlled by an array of transcription factors and microRNAs.
Figure 2
Figure 2
A complex regulatory network controls MEP cell fate. The relative levels of expression of key regulatory factors, including GATA-1, GATA-2, SCL, and PU.1, are predicted to control the output toward erythroid cells (marked by EKLF) or megakaryocytes (marked by Fli-1). Arrows indicate gene activation; and blunted lines, repression.
See this image and copyright information in PMC

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