A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein
- PMID: 2162164
- DOI: 10.1007/BF01311059
A mouse attenuated mutant of Junin virus with an altered envelope glycoprotein
Abstract
The XJC13 strain of Junin virus (JV) and the mouse-attenuated mutant C167 showed different GP38 peptide mapping after limited proteolysis with ficin and papain; viral infectivity of both viruses also exhibited a different susceptibility to protease treatment. A correlation between envelope glycoprotein alteration and JV virulence in neonatal mice is proposed.
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