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Review
. 2011 Nov-Dec;1809(11-12):623-30.
doi: 10.1016/j.bbagrm.2011.05.003. Epub 2011 May 18.

Functions of Kaposi's sarcoma-associated herpesvirus microRNAs

Joseph M Ziegelbauer  1
Affiliations
Review

Functions of Kaposi's sarcoma-associated herpesvirus microRNAs

Joseph M Ziegelbauer. Biochim Biophys Acta. 2011 Nov-Dec.

Abstract

MicroRNAs can modulate gene expression post-transcriptionally by altering mRNA stability and protein translation. Multiple DNA viruses express viral microRNAs and have been shown to modulate expression of host and viral genes. Through various methods of microRNA target identification, we are beginning to understand the various roles of viral miRNAs including viral replication, immune evasion and apoptosis. This review is focused on the roles of microRNAs expressed by Kaposi's sarcoma-associated herpesvirus or human herpesvirus 8. This article is part of a Special Issue entitled: "MicroRNAs in viral gene regulation".

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Figures

Figure 1
Figure 1
The genomic location of the KSHV major latency locus. Open reading frames are displayed as solid arrows. Pre-miRNAs are symbolized by triangles. The pre-miRNA labeled “1” corresponds to miR-K12-1 and so forth.
Figure 2
Figure 2
Network of KSHV miRNA human targets. The network [58] was started using the list of validated miRNA human targets and Dijkstra's shortest path algorithm [59] with a maximum of two steps in between gene products[60]. Interactions between gene products come from manually curated interactions described in the literature. Validated miRNA targets are highlighted by colored circles. Activation interactions are shown by green arrows, repression by red arrows, and unspecified are shown in gray. Analysis was performed using MetaCore from GeneGo.
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