Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov 13;66(Pt 12):o3175-6.
doi: 10.1107/S160053681004626X.

The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator

Julie Braun, Irving Boittiaux, Anaelle Tilborg, Didier Lambert, Johan Wouters

The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator

Julie Braun et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water mol-ecule and a disordered mol-ecule of dimethyl-formamide (DMF), viz. dicyclo-hexyl-aminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethyl-formamide solvate monohydrate, C(12)H(24)N(+)·C(19)H(13)N(2)O(4) (-)·C(3)H(7)NO·H(2)O. The conformation of the deprotonated compound is constrained by charge-assisted strong hydrogen bonds with the dicyclo-hexyl-aminium ion and a dense hydrogen-bond network involving co-crystallized solvent mol-ecules. The dihedral angle between the fused ring systems in the anion is 58.35 (4)°.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
ORTEP view (with atom numbering) of the title compound. Only selected H atoms have been retained for clarity (on the chiral carbon, on the protonated nitrogen, and H involved in H-bonds). Displacement ellipsoids for non-H atoms are drawn at the 30% probability level.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Brueckner, B., Boy, R. G., Siedlecki, P., Munsch, T., Kliem, H. C., Zielenkiewicz, P., Suhai, S., Wiessler, M. & Lyko, F. (2005). Cancer Res.65, 6305–6311. - PubMed
    1. Burnett, M. N. & Johnson, C. K. (1996). ORTEPIII Report ORNL-6895. Oak Ridge National Laboratory, Tennessee, USA.
    1. Flack, H. D. (1983). Acta Cryst. A39, 876–881.
    1. Oxford Diffraction (2009). CrysAlis PRO Oxford Diffraction Ltd, Yarnton, England.
    1. Sheldrick, G. M. (2008). Acta Cryst. A64, 112–122. - PubMed