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. 1996 Jul;9(1):9-18.

Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome

P Georgiou  1 , I Maroulakou, J Green, P Dantis, V Romanospica, S Kottaridis, J Lautenberger, D Watson, T Papas, P Fischinger, N Bhat
Affiliations
  • PMID: 21541474

Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome

P Georgiou et al. Int J Oncol. 1996 Jul.

Abstract

We have examined the expression of three members of the ets family of genes, ETS1, ETS2 and ERGB/Fli-1, in lymphocytes from patients with systemic lupus erythematosus and in two murine autoimmune model systems. The ERGB/Fli-1 gene is expressed at a higher level in lymphocytes from autoimmune disease patients than healthy individuals. In addition, we found that the ERGB/Fli-1 gene expression is higher in splenic T-cells from lupus prone mice and in infiltrating lymphocytes in the salivary glands of HTLV-I tax transgenic mice. Taken together, these results suggest that the elevated expression of the ERGB/Fli-1 gene in lymphocytes may be a prelude to the development of autoimmune diseases.

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