Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan;136(1):23-8.

High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis

M G Hendrix  1 , M M Salimans, C P van Boven, C A Bruggeman
Affiliations

High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis

M G Hendrix et al. Am J Pathol. 1990 Jan.

Abstract

The presence of cytomegalovirus (CMV) nucleic acids was demonstrated in arterial walls of patients with grade III and with maximally grade I atherosclerosis by dot blot and in situ DNA hybridization and by polymerase chain reaction (PCR) using probes and primers derived from immediate early (IE) and late (L) genomic regions. The presence of the complete viral genome could be demonstrated by both dot blot DNA hybridization and PCR. IE mRNA but not L mRNA could be demonstrated by in situ DNA hybridization, indicating the presence of latent CMV in the human arterial wall. By PCR 90% of the samples obtained from atherosclerotic patients were shown to contain viral nucleic acids as compared to 53% of patients with maximally grade I atherosclerosis, thus substantiating a role for this virus in the pathogenesis of atherosclerosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Gen Virol. 1986 Jul;67 ( Pt 7):1327-42 - PubMed
    1. Science. 1985 Dec 20;230(4732):1350-4 - PubMed
    1. Prog Med Virol. 1986;33:99-133 - PubMed
    1. J Infect Dis. 1987 Jan;155(1):158-9 - PubMed
    1. J Virol. 1987 Feb;61(2):446-53 - PubMed

MeSH terms