Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jun;3(3):159-66.
doi: 10.1093/jmcb/mjr007. Epub 2011 Apr 18.

MicroRNAs in NF-kappaB signaling

Xiaodong Ma  1 , Lindsey E Becker Buscaglia, Juanita R Barker, Yong Li
Affiliations
Review

MicroRNAs in NF-kappaB signaling

Xiaodong Ma et al. J Mol Cell Biol. 2011 Jun.

Abstract

Nuclear factor κB (NF-κB) is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity, cell proliferation, inflammation, and tumor development. MicroRNAs (miRNAs) are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3' untranslated regions of mRNAs. In this work, we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases, particularly in cancer. The function of miR-146, miR-155, miR-181b, miR-21, and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed. Given that over 1000 human miRNAs have been identified, rendering miRNAs one of the most abundant classes of regulatory molecules, deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Panoramic view of miRNAs converged with the NF-κB network.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Annunziata C.M., Davis R.E., Demchenko Y., et al. Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12:115–130. doi:10.1016/j.ccr.2007.07.004. - DOI - PMC - PubMed
    1. Aqeilan R.I., Calin G.A., Croce C.M. miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ. 2010;17:215–220. doi:10.1038/cdd.2009.69. - DOI - PubMed
    1. Baek D., Villen J., Shin C., et al. The impact of microRNAs on protein output. Nature. 2008;455:64–71. doi:10.1038/nature07242. - DOI - PMC - PubMed
    1. Bala S., Marcos M., Kodys K., et al. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease. J. Biol. Chem. 2011;286:1436–1444. doi:10.1074/jbc.M110.145870. - DOI - PMC - PubMed
    1. Baud V., Karin M. Is NF-κB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug Discov. 2009;8:33–40. doi:10.1038/nrd2781. - DOI - PMC - PubMed

Publication types