doi: 10.1038/348515a0.
Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A
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- PMID: 2147232
- DOI: 10.1038/348515a0
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Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A
Nature.
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Abstract
The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.
Comment in
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Gene expression. RNA binding: beta s and basics.Nature. 1990 Dec 6;348(6301):485-6. doi: 10.1038/348485a0. Nature. 1990. PMID: 1701031 No abstract available.
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