doi: 10.1016/0092-8674(90)90686-9.
A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein
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- PMID: 2142019
- DOI: 10.1016/0092-8674(90)90686-9
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A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein
Cell.
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Abstract
The adenovirus E1a protein stimulates transcription of viral early genes. Recent experiments indicate that E1a contains a transcriptional activating region, which functions when directed to a promoter. Because E1a is not a sequence-specific DNA binding protein, how it targets to viral promoters has been a question. Several of the viral early promoters contain one or more binding sites for ATFs, a family of cellular transcription factors. Here we show that E1a can function through a specific ATF protein, designated ATF-2. We provide evidence that E1a interacts with a discrete region of promoter-bound ATF-2, thereby positioning the E1a activating region at a viral promoter.
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