Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Jul 1;172(1):239-44.
doi: 10.1084/jem.172.1.239.

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization

A Bandeira  1 , T Mota-Santos, S Itohara, S Degermann, C Heusser, S Tonegawa, A Coutinho
Affiliations
Comparative Study

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization

A Bandeira et al. J Exp Med. .

Abstract

Using monoclonal antibodies identifying all gamma/delta and alpha/beta T cell receptors in cytofluorometric analysis, we have compared the composition of intestinal intraepithelial lymphocytes (i-IEL) in euthymic and athymic germ-free (GF) and conventional (SPF) mice. The results show a marked influence of microbial colonization in the numbers of single-positive (CD4+ or CD8+) alpha/beta i-IEL, but little effect in the pool size or characteristics of gamma/delta i-IEL. In young athymic mice, virtually no alpha/beta i-IEL are detected, while considerable numbers of gamma/delta i-IEL remain, though reduced in GF animals.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Eur J Immunol. 1974 Jun;4(6):435-43 - PubMed
    1. Immunol Today. 1990 Mar;11(3):75-8 - PubMed
    1. J Exp Med. 1976 Mar 1;143(3):585-600 - PubMed
    1. J Exp Med. 1977 Jan 1;145(1):31-44 - PubMed
    1. J Exp Med. 1978 Dec 1;148(6):1661-77 - PubMed

Publication types

MeSH terms

Substances