Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;69(2):292-302.
doi: 10.1002/ana.22366.

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria

Chris H Polman  1 , Stephen C Reingold, Brenda Banwell, Michel Clanet, Jeffrey A Cohen, Massimo Filippi, Kazuo Fujihara, Eva Havrdova, Michael Hutchinson, Ludwig Kappos, Fred D Lublin, Xavier Montalban, Paul O'Connor, Magnhild Sandberg-Wollheim, Alan J Thompson, Emmanuelle Waubant, Brian Weinshenker, Jerry S Wolinsky
Affiliations
Free PMC article

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria

Chris H Polman et al. Ann Neurol. 2011 Feb.
Free PMC article

Abstract

New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schumacher FA, Beeve GW, Kibler RF, et al. Problems of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci. 1965;122:552–568. - PubMed
    1. Poser CM, Paty DW, Scheinberg LC, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983;1:227–231. - PubMed
    1. Paty DW, Oger JJ, Kastrukoff LF, et al. MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding and CT. Neurology. 1988;38:180–185. - PubMed
    1. Barkhof F, Filippi M, Miller DH, et al. Comparison of MR imaging criteria at first presentation to predict conversion to clinically definite MS. Brain. 1997;120:2059–2069. - PubMed
    1. Fazekas F, Offenbacher H, Fuchs S, et al. Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology. 1988;38:1822–1825. - PubMed

Publication types