Glomerular basement membrane composition and the filtration barrier

doi:10.1007/s00467-011-1785-1

Review

. 2011 Sep;26(9):1413-7.

doi: 10.1007/s00467-011-1785-1. Epub 2011 Feb 15.

Glomerular basement membrane composition and the filtration barrier

Jeffrey H Miner¹

Affiliations

Affiliation

¹ Renal Division, Department of Internal Medicine, School of Medicine, Washington University, 660 S. Euclid Ave., Box 8126, St. Louis, MO 63110, USA. minerj@wustl.edu

PMID: 21327778
PMCID: PMC3108006
DOI: 10.1007/s00467-011-1785-1

Review

Glomerular basement membrane composition and the filtration barrier

Jeffrey H Miner. Pediatr Nephrol. 2011 Sep.

. 2011 Sep;26(9):1413-7.

doi: 10.1007/s00467-011-1785-1. Epub 2011 Feb 15.

Author

Jeffrey H Miner¹

Affiliation

¹ Renal Division, Department of Internal Medicine, School of Medicine, Washington University, 660 S. Euclid Ave., Box 8126, St. Louis, MO 63110, USA. minerj@wustl.edu

PMID: 21327778
PMCID: PMC3108006
DOI: 10.1007/s00467-011-1785-1

Abstract

The glomerular basement membrane (GBM) is an especially thick basement membrane that contributes importantly to the kidney's filtration barrier. The GBM derives from the fusion of separate podocyte and endothelial cell basement membranes during glomerulogenesis and consists primarily of laminin-521 (α5β2γ1), collagen α3α4α5(IV), nidogens-1 and -2, and agrin. Of these nine proteins, mutations in the genes encoding four of them (LAMB2, COL4A3, COL4A4, and COL4A5) cause glomerular disease in humans as well as in mice. Furthermore, mutation of a fifth (Lama5) gene in podocytes in mice causes proteinuria, nephrotic syndrome, and progression to renal failure. These results highlight the importance of the GBM for establishing and maintaining a properly functioning glomerular filtration barrier.

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References

1. Farquhar MG. Editorial: The primary glomerular filtration barrier–basement membrane or epithelial slits? Kidney Int. 1975;8:197–211. - PubMed
1. St. John PL, Abrahamson DR. Glomerular endothelial cells and podocytes jointly synthesize laminin-1 and -11 chains. Kidney Int. 2001;60:1037–1046. - PubMed
1. Abrahamson DR. Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys. J Cell Biol. 1985;100:1988–2000. - PMC - PubMed
1. Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL. Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol. 2009;20:1471–1479. - PMC - PubMed
1. Schnabel E, Anderson JM, Farquhar MG. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol. 1990;111:1255–1263. - PMC - PubMed

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[1] Farquhar MG. Editorial: The primary glomerular filtration barrier–basement membrane or epithelial slits? Kidney Int. 1975;8:197–211. - PubMed

[2] Farquhar MG. Editorial: The primary glomerular filtration barrier–basement membrane or epithelial slits? Kidney Int. 1975;8:197–211. - PubMed

[3] St. John PL, Abrahamson DR. Glomerular endothelial cells and podocytes jointly synthesize laminin-1 and -11 chains. Kidney Int. 2001;60:1037–1046. - PubMed

[4] St. John PL, Abrahamson DR. Glomerular endothelial cells and podocytes jointly synthesize laminin-1 and -11 chains. Kidney Int. 2001;60:1037–1046. - PubMed

[5] Abrahamson DR. Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys. J Cell Biol. 1985;100:1988–2000. - PMC - PubMed

[6] Abrahamson DR. Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys. J Cell Biol. 1985;100:1988–2000. - PMC - PubMed

[7] Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL. Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol. 2009;20:1471–1479. - PMC - PubMed

[8] Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL. Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol. 2009;20:1471–1479. - PMC - PubMed

[9] Schnabel E, Anderson JM, Farquhar MG. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol. 1990;111:1255–1263. - PMC - PubMed

[10] Schnabel E, Anderson JM, Farquhar MG. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol. 1990;111:1255–1263. - PMC - PubMed

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Glomerular basement membrane composition and the filtration barrier

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