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Review
. 2011 Jan 25;8(1):e1000406.
doi: 10.1371/journal.pmed.1000406.

A research agenda to underpin malaria eradication

Pedro L Alonso  1 , Graham Brown, Myriam Arevalo-Herrera, Fred Binka, Chetan Chitnis, Frank Collins, Ogobara K Doumbo, Brian Greenwood, B Fenton Hall, Myron M Levine, Kamini Mendis, Robert D Newman, Christopher V Plowe, Mario Henry Rodríguez, Robert Sinden, Laurence Slutsker, Marcel Tanner
Affiliations
Review

A research agenda to underpin malaria eradication

Pedro L Alonso et al. PLoS Med. .

Abstract

The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling up control with currently available tools and strategies, much greater gains could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research Agenda (malERA) complements the current research agenda--primarily directed towards reducing morbidity and mortality--with one that aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda.

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Conflict of interest statement

GB declares that he is Chair of MALVAC, Chair USAID Malaria Vaccine Development Program Scientific Consultants Group, a member of the Board of Roll Back Malaria, and a member of the APMEN Advisory Board.

Figures

Figure 1
Figure 1. Epidemiological milestones ,.
Image credit: Fusión Creativa.
Figure 2
Figure 2. Consultative process towards a consolidated research and development agenda for malaria eradication.
Image credit: Fusión Creativa.
Figure 3
Figure 3. The malERA governance bodies.
Image credit: Fusión Creativa.
Figure 4
Figure 4. Key research and development issues and their position in relation to the different epidemiological phases towards eradication.
Image credit: Fusión Creativa.
See this image and copyright information in PMC

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