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Review
. 2011 Jan-Feb;8(1):44-8.
doi: 10.4161/rna.8.1.13863. Epub 2011 Jan 1.

Coding region: the neglected post-transcriptional code

Eun Kyung Lee  1 , Myriam Gorospe
Affiliations
Review

Coding region: the neglected post-transcriptional code

Eun Kyung Lee et al. RNA Biol. 2011 Jan-Feb.

Abstract

The control of mammalian mRNA turnover and translation has been linked almost exclusively to specific cis-elements within the 5'- and 3'-untranslated regions (UTRs) of the mature mRNA. However, instances of regulated turnover and translation via cis-elements within the coding region (CR) of mRNAs are accumulating. Here, we describe the regulation of post-transcriptional fate through trans-binding factors (RNA-binding proteins and microRNAs) that function via CR sequences. We discuss how the CR enriches the post-transcriptional control of gene expression, and predict that new high-throughput technologies will enable a more mainstream study of CR-governed gene regulation.

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Figures

Figure 1
Figure 1
CR-bound RBPs and microRNAs in the mammalian cell. RBPs and microRNAs may be found associated with mRNAs during transport, while mRNAs are stored in specialized cytoplasmic locales (e.g., stress granules or processing bodies), or in polysomes with low ribosome occupancy. Mature mRNAs may also associate with RBPs and microRNAs in the nucleus.
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