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. 2011 Mar;22(3):607-15.
doi: 10.1007/s10856-011-4228-4. Epub 2011 Jan 22.

Preparation and preliminary cytocompatibility of magnesium doped apatite cement with degradability for bone regeneration

Jingxiong Lu  1 , Jie Wei, Yonggang Yan, Hong Li, Junfeng Jia, Shicheng Wei, Han Guo, Tiqiao Xiao, Changsheng Liu
Affiliations

Preparation and preliminary cytocompatibility of magnesium doped apatite cement with degradability for bone regeneration

Jingxiong Lu et al. J Mater Sci Mater Med. 2011 Mar.

Abstract

In the present study, we fabricated magnesium doped apatite cement (md-AC) with rapid self-setting characteristic by adding the mixed powders of magnesium oxide and calcium dihydrogen phosphate (MO-CDP) into hydroxyapatite cement (HAC). The results revealed that the md-AC with 50 wt% MO-CDP could set within 6 min and the compression strength could reach 51 MPa after setting for 1 h, indicating that the md-AC had highly initial mechanical strength. The degradability of the md-AC in Tris-HCl solution increased with the increase of MO-CDP amount, and the weight loss ratio of md-AC with 50 wt% MO-CDP was 57.5 wt% after soaked for 12 weeks. Newly flake-like apatite could be deposited on the md-AC surfaces after soaked in simulated body fluid (SBF) for 7 days. Cell proliferation ratio of MG(63) cells on md-AC was obviously higher than that of HAC on days 4 and 7. The cells with normal phenotype spread well on the md-AC surfaces and attached intimately with the substrate, and alkaline phosphatase (ALP) activity of the cells on md-AC significantly improved compared with HAC on day 7. The results demonstrate that the md-AC has a good ability to support cell proliferation and differentiation, and indicate a good cytocompatibility.

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