Kappa opioid receptors mediate where fear is expressed following extinction training
- PMID: 21245209
- DOI: 10.1101/lm.2049511
Kappa opioid receptors mediate where fear is expressed following extinction training
Abstract
Six experiments used a within-subjects renewal design to examine the involvement of kappa opioid receptors (KORs) in regulating the expression and recovery of extinguished fear. Rats were trained to fear a tone conditioned stimulus (CS) via pairings with foot shock in a distinctive context (A). This was followed by extinction training of the CS in a second context (B). Finally, all rats were tested for fear to the tone in the extinction context (ABB) and the training (ABA) or a novel (ABC) context. Intracerebroventricular (ICV) infusion of the KOR antagonist nor-binaltorphimine dihydrochloride (nor-BNI) dose-dependently prevented ABA renewal of fear, but had no effect on the expression of ABC renewal, the expression of extinction, or the expression of nonextinguished fear. Conversely, pretest infusion of the KOR agonist U50,488 hydrochloride (U50,488) selectively facilitated the expression of ABA renewal and had no effect on the expression of extinction. Pretest infusion of nor-BNI had no effect on the expression of context-specific latent inhibition. Collectively, these results suggest that KORs gate the expression of fear following extinction training and may comprise a critical neuropeptide component of the circuitry underlying context-dependent expression of fear.
Similar articles
-
C57BL/6J and DBA/2J mice differ in extinction and renewal of extinguished conditioned fear.Behav Brain Res. 2004 Oct 5;154(2):567-76. doi: 10.1016/j.bbr.2004.03.025. Behav Brain Res. 2004. PMID: 15313046
-
Contextual control of human fear associations in a renewal paradigm.Behav Res Ther. 2007 Sep;45(9):2002-18. doi: 10.1016/j.brat.2007.02.011. Epub 2007 Mar 6. Behav Res Ther. 2007. PMID: 17451643 Clinical Trial.
-
Extinction of reinstated or ABC renewed fear responses renders them resistant to subsequent ABA renewal.J Exp Psychol Anim Behav Process. 2013 Jul;39(3):208-20. doi: 10.1037/a0031986. Epub 2013 May 13. J Exp Psychol Anim Behav Process. 2013. PMID: 23668186
-
Extinction, generalization, and return of fear: a critical review of renewal research in humans.Biol Psychol. 2013 Jan;92(1):51-8. doi: 10.1016/j.biopsycho.2012.01.006. Epub 2012 Jan 26. Biol Psychol. 2013. PMID: 22285129 Review.
-
Renewal in human fear conditioning: A systematic review and meta-analysis.Neurosci Biobehav Rev. 2024 Apr;159:105606. doi: 10.1016/j.neubiorev.2024.105606. Epub 2024 Feb 29. Neurosci Biobehav Rev. 2024. PMID: 38431150 Review.
Cited by
-
Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.Neuropsychopharmacology. 2013 Mar;38(4):647-54. doi: 10.1038/npp.2012.229. Epub 2012 Nov 6. Neuropsychopharmacology. 2013. PMID: 23212453 Free PMC article.
-
ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.PLoS One. 2014 Jun 12;9(6):e100108. doi: 10.1371/journal.pone.0100108. eCollection 2014. PLoS One. 2014. PMID: 24925360 Free PMC article.
-
Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry.Handb Exp Pharmacol. 2022;271:223-253. doi: 10.1007/164_2021_440. Handb Exp Pharmacol. 2022. PMID: 33580392 Review.
-
Posterior parietal cortex mediates fear renewal in a novel context.Mol Brain. 2020 Feb 5;13(1):16. doi: 10.1186/s13041-020-0556-y. Mol Brain. 2020. PMID: 32024548 Free PMC article.
-
Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders.Br J Pharmacol. 2014 Oct;171(20):4690-718. doi: 10.1111/bph.12779. Epub 2014 Jul 23. Br J Pharmacol. 2014. PMID: 24835117 Free PMC article. Review.