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Review
. 2011 Apr;31(2):137-46.
doi: 10.1007/s10875-010-9499-x. Epub 2011 Jan 18.

Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire

Christoph R Arnold  1 , Juliane Wolf, Stefan Brunner, Dietmar Herndler-Brandstetter, Beatrix Grubeck-Loebenstein
Affiliations
Review

Gain and loss of T cell subsets in old age--age-related reshaping of the T cell repertoire

Christoph R Arnold et al. J Clin Immunol. 2011 Apr.

Abstract

The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T cells, thereby compromising the diversity of the T cell pool. Additional infection with latent pathogens such as cytomegalovirus aggravates this process. In this review, we focus on the major age-related changes that occur in the naïve and the antigen-experienced T cell population. We discuss the mechanisms responsible for the generation and maintenance of these subsets and how age-related changes can be delayed or prevented by clinical interventions.

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