Molecular mechanisms and physiologic functions of mitochondrial dynamics
- PMID: 21233142
- DOI: 10.1093/jb/mvr002
Molecular mechanisms and physiologic functions of mitochondrial dynamics
Abstract
Mitochondria are highly dynamic organelles that continuously change their shape through frequent fusion, fission and movement throughout the cell, and these dynamics are crucial for the life and death of the cells as they have been linked to apoptosis, maintenance of cellular homeostasis, and ultimately to neurologic disorders and metabolic diseases. Over the past decade, a growing number of novel proteins that regulate mitochondrial dynamics have been discovered. Large GTPase family proteins and their regulators control these aspects of mitochondrial dynamics. In this review, we briefly summarize the current knowledge about molecular machineries regulating mitochondrial fusion/fission and the role of mitochondrial dynamics in cell pathophysiology.
Similar articles
-
Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1.IUBMB Life. 2008 Jul;60(7):448-55. doi: 10.1002/iub.71. IUBMB Life. 2008. PMID: 18465792 Review.
-
Molecular machinery of mitochondrial dynamics in yeast.Biol Chem. 2007 Sep;388(9):917-26. doi: 10.1515/BC.2007.110. Biol Chem. 2007. PMID: 17696775 Review.
-
Mitochondrial Fission and Fusion.Biochemistry (Mosc). 2015 Nov;80(11):1457-64. doi: 10.1134/S0006297915110061. Biochemistry (Mosc). 2015. PMID: 26615436 Review.
-
[Role of transmembrane GTPases in mitochondrial morphology and activity].Postepy Biochem. 2007;53(1):53-9. Postepy Biochem. 2007. PMID: 17718388 Review. Polish.
-
Mitochondrial dynamics in mammals.Curr Top Dev Biol. 2004;59:119-44. doi: 10.1016/S0070-2153(04)59005-1. Curr Top Dev Biol. 2004. PMID: 14975249 Review. No abstract available.
Cited by
-
Molecular mechanisms of mitochondrial homeostasis regulation in neurons and possible therapeutic approaches for Alzheimer's disease.Heliyon. 2024 Aug 17;10(17):e36470. doi: 10.1016/j.heliyon.2024.e36470. eCollection 2024 Sep 15. Heliyon. 2024. PMID: 39281517 Free PMC article. Review.
-
Mechanism of Mitochondrial Kinetic Imbalance and Nrf2 Signaling Pathway-Mediated Oxidative Stress in Nickel and/or Chromium-Induced Kidney Injury in Mice.Antioxidants (Basel). 2024 Aug 13;13(8):980. doi: 10.3390/antiox13080980. Antioxidants (Basel). 2024. PMID: 39199226 Free PMC article.
-
Protective Effects of Astaxanthin on Ochratoxin A-Induced Liver Injury: Effects of Endoplasmic Reticulum Stress and Mitochondrial Fission-Fusion Balance.Toxins (Basel). 2024 Jan 30;16(2):68. doi: 10.3390/toxins16020068. Toxins (Basel). 2024. PMID: 38393146 Free PMC article.
-
Mitochondrial Homeostasis Regulating Mitochondrial Number and Morphology Is a Distinguishing Feature of Skeletal Muscle Fiber Types in Marine Teleosts.Int J Mol Sci. 2024 Jan 26;25(3):1512. doi: 10.3390/ijms25031512. Int J Mol Sci. 2024. PMID: 38338790 Free PMC article.
-
The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases.Int J Mol Sci. 2024 Jan 18;25(2):1175. doi: 10.3390/ijms25021175. Int J Mol Sci. 2024. PMID: 38256247 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
