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. 2011 Mar 17;117(11):3104-12.
doi: 10.1182/blood-2010-09-307983. Epub 2011 Jan 12.

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

Zohar Keren  1 , Shulamit Naor, Shahar Nussbaum, Karin Golan, Tomer Itkin, Yoshiteru Sasaki, Marc Schmidt-Supprian, Tsvee Lapidot, Doron Melamed
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Free article

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

Zohar Keren et al. Blood. .
Free article

Abstract

Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses. We show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. Thus, depletion of B cells in old mice was followed by expansion of multipotent primitive progenitors and common lymphoid progenitors, a revival of B-lymphopoiesis in the bone marrow, and generation of a rejuvenated peripheral compartment that enhanced the animal's immune responsiveness to antigenic stimulation. Collectively, our results suggest that immunosenescence in the B-lineage is not irreversible and that depletion of the long-lived B cells in old mice rejuvenates the B-lineage and enhances immune competence.

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  • B cells talk to their progenitors.
    Van Den Broeck A, Cambier J. Van Den Broeck A, et al. Blood. 2011 Mar 17;117(11):2985-6. doi: 10.1182/blood-2011-02-332544. Blood. 2011. PMID: 21415272 No abstract available.

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