G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides
- PMID: 2122563
- DOI: 10.1016/0165-6147(90)90179-c
G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides
Abstract
The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins.
Comment in
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Direct activation of G proteins.Trends Pharmacol Sci. 1990 Oct;11(10):400-1. doi: 10.1016/0165-6147(90)90144-w. Trends Pharmacol Sci. 1990. PMID: 2124010 No abstract available.
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