Heteromerization of TRP channel subunits: extending functional diversity

doi:10.1007/s13238-010-0108-9

Review

. 2010 Sep;1(9):802-10.

doi: 10.1007/s13238-010-0108-9. Epub 2010 Oct 7.

Heteromerization of TRP channel subunits: extending functional diversity

Wei Cheng¹, Changsen Sun, Jie Zheng

Affiliations

PMID: 21203922
PMCID: PMC4875230
DOI: 10.1007/s13238-010-0108-9

Review

Heteromerization of TRP channel subunits: extending functional diversity

Wei Cheng et al. Protein Cell. 2010 Sep.

. 2010 Sep;1(9):802-10.

doi: 10.1007/s13238-010-0108-9. Epub 2010 Oct 7.

Authors

Wei Cheng¹, Changsen Sun, Jie Zheng

Affiliation

¹ Lab of Biomedical Optics, College of Physics and Optoelectronic Engineering, Dalian University of Technology, Dalian 116023, China.

PMID: 21203922
PMCID: PMC4875230
DOI: 10.1007/s13238-010-0108-9

Abstract

Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.

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References

1. Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217–6228. doi: 10.1523/JNEUROSCI.0893-09.2009. - DOI - PMC - PubMed
1. Arniges M., Fernández-Fernández J.M., Albrecht N., Schaefer M., Valverde M.A. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem. 2006;281:1580–1586. doi: 10.1074/jbc.M511456200. - DOI - PubMed
1. Bai C.X., Giamarchi A., Rodat-Despoix L., Padilla F., Downs T., Tsiokas L., Delmas P. Formation of a new receptoroperated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008;9:472–479. doi: 10.1038/embor.2008.29. - DOI - PMC - PubMed
1. Bargal R., Avidan N., Ben-Asher E., Olender Z., Zeigler M., Frumkin A., Raas-Rothschild A., Glusman G., Lancet D., Bach G. Identification of the gene causing mucolipidosis type IV. Nat Genet. 2000;26:118–123. doi: 10.1038/79095. - DOI - PubMed
1. Bautista D.M., Jordt S.E., Nikai T., Tsuruda P.R., Read A.J., Poblete J., Yamoah E.N., Basbaum A.I., Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269–1282. doi: 10.1016/j.cell.2006.02.023. - DOI - PubMed

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[1] Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217–6228. doi: 10.1523/JNEUROSCI.0893-09.2009. - DOI - PMC - PubMed

[2] Alessandri-Haber N., Dina O.A., Chen X., Levine J.D. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217–6228. doi: 10.1523/JNEUROSCI.0893-09.2009. - DOI - PMC - PubMed

[3] Arniges M., Fernández-Fernández J.M., Albrecht N., Schaefer M., Valverde M.A. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem. 2006;281:1580–1586. doi: 10.1074/jbc.M511456200. - DOI - PubMed

[4] Arniges M., Fernández-Fernández J.M., Albrecht N., Schaefer M., Valverde M.A. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem. 2006;281:1580–1586. doi: 10.1074/jbc.M511456200. - DOI - PubMed

[5] Bai C.X., Giamarchi A., Rodat-Despoix L., Padilla F., Downs T., Tsiokas L., Delmas P. Formation of a new receptoroperated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008;9:472–479. doi: 10.1038/embor.2008.29. - DOI - PMC - PubMed

[6] Bai C.X., Giamarchi A., Rodat-Despoix L., Padilla F., Downs T., Tsiokas L., Delmas P. Formation of a new receptoroperated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008;9:472–479. doi: 10.1038/embor.2008.29. - DOI - PMC - PubMed

[7] Bargal R., Avidan N., Ben-Asher E., Olender Z., Zeigler M., Frumkin A., Raas-Rothschild A., Glusman G., Lancet D., Bach G. Identification of the gene causing mucolipidosis type IV. Nat Genet. 2000;26:118–123. doi: 10.1038/79095. - DOI - PubMed

[8] Bargal R., Avidan N., Ben-Asher E., Olender Z., Zeigler M., Frumkin A., Raas-Rothschild A., Glusman G., Lancet D., Bach G. Identification of the gene causing mucolipidosis type IV. Nat Genet. 2000;26:118–123. doi: 10.1038/79095. - DOI - PubMed

[9] Bautista D.M., Jordt S.E., Nikai T., Tsuruda P.R., Read A.J., Poblete J., Yamoah E.N., Basbaum A.I., Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269–1282. doi: 10.1016/j.cell.2006.02.023. - DOI - PubMed

[10] Bautista D.M., Jordt S.E., Nikai T., Tsuruda P.R., Read A.J., Poblete J., Yamoah E.N., Basbaum A.I., Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269–1282. doi: 10.1016/j.cell.2006.02.023. - DOI - PubMed

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Heteromerization of TRP channel subunits: extending functional diversity

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Heteromerization of TRP channel subunits: extending functional diversity

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