First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

doi:10.1128/AAC.01142-10

. 2011 Mar;55(3):1285-6.

doi: 10.1128/AAC.01142-10. Epub 2011 Jan 3.

First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

Ignasi Roca¹, Paula Espinal, Sara Martí, Jordi Vila

Affiliations

PMID: 21199925
PMCID: PMC3067064
DOI: 10.1128/AAC.01142-10

First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

Ignasi Roca et al. Antimicrob Agents Chemother. 2011 Mar.

. 2011 Mar;55(3):1285-6.

doi: 10.1128/AAC.01142-10. Epub 2011 Jan 3.

Authors

Ignasi Roca¹, Paula Espinal, Sara Martí, Jordi Vila

Affiliation

¹ Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, CRESIB, Barcelona, Spain.

PMID: 21199925
PMCID: PMC3067064
DOI: 10.1128/AAC.01142-10

Abstract

Non-Acinetobacter baumannii spp. are emerging among clinical Acinetobacter isolates causing nosocomial infections, and some (such as genomospecies 13TU) appear to be multidrug resistant. The prevalence of non-Acinetobacter baumannii spp. in the hospital setting is likely understated due to poor identification techniques. We report the first identification of an AdeABC-type efflux pump in an Acinetobacter genomospecies 13TU clinical isolate, its contribution to multidrug resistance, and the coexistence of three Ade-type efflux pumps in this strain.

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References

1. Adams, M. D., et al. 2008. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J. Bacteriol. 190:8053-8064. - PMC - PubMed
1. Barbe, V., et al. 2004. Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. Nucleic Acids Res. 32:5766-5779. - PMC - PubMed
1. Chang, H. C., et al. 2005. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region. J. Clin. Microbiol. 43:1632-1639. - PMC - PubMed
1. Chau, S. L., Y. W. Chu, and E. T. Houang. 2004. Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3. Antimicrob. Agents Chemother. 48:4054-4055. - PMC - PubMed
1. Chu, Y. W., S. L. Chau, and E. T. Houang. 2006. Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. J. Med. Microbiol. 55:477-478. - PubMed

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[1] Adams, M. D., et al. 2008. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J. Bacteriol. 190:8053-8064. - PMC - PubMed

[2] Adams, M. D., et al. 2008. Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii. J. Bacteriol. 190:8053-8064. - PMC - PubMed

[3] Barbe, V., et al. 2004. Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. Nucleic Acids Res. 32:5766-5779. - PMC - PubMed

[4] Barbe, V., et al. 2004. Unique features revealed by the genome sequence of Acinetobacter sp. ADP1, a versatile and naturally transformation competent bacterium. Nucleic Acids Res. 32:5766-5779. - PMC - PubMed

[5] Chang, H. C., et al. 2005. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region. J. Clin. Microbiol. 43:1632-1639. - PMC - PubMed

[6] Chang, H. C., et al. 2005. Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region. J. Clin. Microbiol. 43:1632-1639. - PMC - PubMed

[7] Chau, S. L., Y. W. Chu, and E. T. Houang. 2004. Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3. Antimicrob. Agents Chemother. 48:4054-4055. - PMC - PubMed

[8] Chau, S. L., Y. W. Chu, and E. T. Houang. 2004. Novel resistance-nodulation-cell division efflux system AdeDE in Acinetobacter genomic DNA group 3. Antimicrob. Agents Chemother. 48:4054-4055. - PMC - PubMed

[9] Chu, Y. W., S. L. Chau, and E. T. Houang. 2006. Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. J. Med. Microbiol. 55:477-478. - PubMed

[10] Chu, Y. W., S. L. Chau, and E. T. Houang. 2006. Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups. J. Med. Microbiol. 55:477-478. - PubMed

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First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

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First identification and characterization of an AdeABC-like efflux pump in Acinetobacter genomospecies 13TU

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