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Review
. 2010 Dec;38(7 Suppl):5S-81S.
doi: 10.1177/0192623310386499.

Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system

Bob Thoolen  1 , Robert R Maronpot, Takanori Harada, Abraham Nyska, Colin Rousseaux, Thomas Nolte, David E Malarkey, Wolfgang Kaufmann, Karin Küttler, Ulrich Deschl, Dai Nakae, Richard Gregson, Michael P Vinlove, Amy E Brix, Bhanu Singh, Fiorella Belpoggi, Jerrold M Ward
Affiliations
Review

Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system

Bob Thoolen et al. Toxicol Pathol. 2010 Dec.

Abstract

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions. The standardized nomenclature presented in this document is also available for society members electronically on the internet (http://goreni.org). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for lesions of the hepatobiliary system in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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