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. 2010 Dec;4(6):871-87.
doi: 10.2217/bmm.10.111.

Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function

Antonio Lucio Teixeira  1 , Izabela Guimarães Barbosa, Breno Satler Diniz, Arthur Kummer
Affiliations

Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function

Antonio Lucio Teixeira et al. Biomark Med. 2010 Dec.

Abstract

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimer's disease, Huntington's disease and Parkinson's disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.

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