Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Dec;10(12):825-41.
doi: 10.1038/nrc2964. Epub 2010 Nov 24.

Shared and separate functions of polo-like kinases and aurora kinases in cancer

Susanne M A Lens  1 , Emile E Voest, René H Medema
Affiliations
Review

Shared and separate functions of polo-like kinases and aurora kinases in cancer

Susanne M A Lens et al. Nat Rev Cancer. 2010 Dec.

Abstract

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these kinases have unique functions in mitosis. Within the polo-like kinase family, the emphasis for targeted therapies has been on polo-like kinase 1 (PLK1), and in the aurora kinase family drugs have been developed to specifically target aurora kinase A (AURKA; also known as STK6) and/or aurora kinase B (AURKB; also known as STK12). Information on the selectivity of these compounds in vivo is limited, but it is likely that off-target effects within the same kinase families will affect efficacy and toxicity profiles. In addition, it is becoming clear that interplay between polo-like kinases and aurora kinases is much more extensive than initially anticipated, and that both kinase families are important factors in the response to classical chemotherapeutics that damage the genome or the mitotic spindle. In this Review we discuss the implications of these novel insights on the clinical applicability of polo-like kinase and aurora kinase inhibitors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mol Cancer Ther. 2009 Jul;8(7):1808-17 - PubMed
    1. Mol Cell Biol. 2006 Nov;26(22):8316-35 - PubMed
    1. Curr Protoc Hum Genet. 2008 Apr;Chapter 10:Unit 10.11 - PubMed
    1. J Cell Biol. 1996 Dec;135(6 Pt 2):1701-13 - PubMed
    1. Cell. 2002 Feb 8;108(3):317-29 - PubMed

Publication types

MeSH terms

LinkOut - more resources