doi: 10.1126/science.2105528.
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
Affiliations
- PMID: 2105528
- DOI: 10.1126/science.2105528
Item in Clipboard
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
Science.
.
Abstract
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.
Similar articles
-
Modulation of the IgH enhancer's cell type specificity through a genetic switch.Genes Dev. 1991 Jan;5(1):29-37. doi: 10.1101/gad.5.1.29. Genes Dev. 1991. PMID: 1899229
-
A developmentally modulated chromatin structure at the mouse immunoglobulin kappa 3' enhancer.Mol Cell Biol. 1996 Jun;16(6):3138-55. doi: 10.1128/MCB.16.6.3138. Mol Cell Biol. 1996. PMID: 8649425 Free PMC article.
-
Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Nucleic Acids Res. 1994 Oct 11;22(20):4216-23. doi: 10.1093/nar/22.20.4216. Nucleic Acids Res. 1994. PMID: 7937148 Free PMC article.
-
Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.Immunity. 1995 May;2(5):427-38. doi: 10.1016/1074-7613(95)90024-1. Immunity. 1995. PMID: 7749979 Review. No abstract available.
-
Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription.Immunol Today. 1992 Jan;13(1):31-6. doi: 10.1016/0167-5699(92)90201-h. Immunol Today. 1992. PMID: 1739428 Review.
Cited by
-
Co-operativity of functional domains in the muscle-specific transcription factor Myf-5.EMBO J. 1992 May;11(5):1843-55. doi: 10.1002/j.1460-2075.1992.tb05236.x. EMBO J. 1992. PMID: 1582413 Free PMC article.
-
Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5675-9. doi: 10.1073/pnas.88.13.5675. Proc Natl Acad Sci U S A. 1991. PMID: 1648228 Free PMC article.
-
Anti-IgM antibodies down modulate mu-enhancer activity and OTF2 levels in LPS-stimulated mouse splenic B-cells.Nucleic Acids Res. 1991 Nov 11;19(21):5981-9. doi: 10.1093/nar/19.21.5981. Nucleic Acids Res. 1991. PMID: 1658749 Free PMC article.
-
Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.Mol Cell Biol. 1991 Dec;11(12):6185-91. doi: 10.1128/mcb.11.12.6185-6191.1991. Mol Cell Biol. 1991. PMID: 1944284 Free PMC article.
-
Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.Int J Mol Sci. 2021 Nov 28;22(23):12855. doi: 10.3390/ijms222312855. Int J Mol Sci. 2021. PMID: 34884664 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
