Structure and evolution of a human erythroid transcription factor
- PMID: 2104960
- DOI: 10.1038/343092a0
Structure and evolution of a human erythroid transcription factor
Abstract
Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and of other erythroid-specific genes. Aberrant binding of the human factor to a mutant site has been implicated in one form of hereditary persistence of fetal haemoglobin (HPFH; ref. 2). The complementary DNAs for both the chicken cEryf 1 (ref. 11) and mouse mEryf 1 (ref. 12) encoding genes have recently been cloned. We report here the cloning of the cDNA for the human Eryf 1 encoding gene. The central third of the hEryf 1 cDNA, containing two 'finger' motifs, is almost identical to that of chicken or mouse. The amino-and carboxy-terminal thirds of the human protein are similar to those of mouse, but are strikingly different from the corresponding domains in chicken. The evidence indicates that these erythroid regulatory factors evolved from a common precursor composed of two distinct kinds of repeated domains, which subsequently evolved at greatly different rates.
Similar articles
-
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.Nature. 1989 Jun 8;339(6224):446-51. doi: 10.1038/339446a0. Nature. 1989. PMID: 2725678
-
Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor.Nature. 1989 Mar 30;338(6214):435-8. doi: 10.1038/338435a0. Nature. 1989. PMID: 2467208
-
Erythroid regulatory elements.Stem Cells. 1993 Mar;11(2):95-104. doi: 10.1002/stem.5530110204. Stem Cells. 1993. PMID: 8096156 Review.
-
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages.Nature. 1990 Mar 29;344(6265):444-7. doi: 10.1038/344444a0. Nature. 1990. PMID: 2320112
-
The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB.Mol Cell Biol Res Commun. 2001 Sep;4(5):266-75. doi: 10.1006/mcbr.2001.0290. Mol Cell Biol Res Commun. 2001. PMID: 11529676
Cited by
-
Sequence variation in transcription factor IIIA.Nucleic Acids Res. 1990 Apr 25;18(8):2117-23. doi: 10.1093/nar/18.8.2117. Nucleic Acids Res. 1990. PMID: 2110661 Free PMC article.
-
GATA1 mutations in red cell disorders.IUBMB Life. 2020 Jan;72(1):106-118. doi: 10.1002/iub.2177. Epub 2019 Oct 25. IUBMB Life. 2020. PMID: 31652397 Free PMC article. Review.
-
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family.Mol Cell Biol. 1995 Nov;15(11):5957-65. doi: 10.1128/MCB.15.11.5957. Mol Cell Biol. 1995. PMID: 7565748 Free PMC article.
-
An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.Nucleic Acids Res. 1991 Oct 11;19(19):5285-91. doi: 10.1093/nar/19.19.5285. Nucleic Acids Res. 1991. PMID: 1656391 Free PMC article.
-
Nitrogen GATA factors participate in transcriptional regulation of vacuolar protease genes in Saccharomyces cerevisiae.J Bacteriol. 1997 Sep;179(17):5609-13. doi: 10.1128/jb.179.17.5609-5613.1997. J Bacteriol. 1997. PMID: 9287023 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
