Gsdma3 is required for hair follicle differentiation in mice
- PMID: 20977888
- DOI: 10.1016/j.bbrc.2010.10.094
Gsdma3 is required for hair follicle differentiation in mice
Abstract
Hair follicle differentiation is regulated by multiple signaling pathways. However, the known cellular and molecular mechanisms are limited. Gsdma3 is a novel murine gene and considered to be a mutation hotspot. Six mutants have been reported in Gsdma3 and all these mutants exhibit hair loss and hyperkeratosis phenotypes. In order to verify how the lack of Gsdma3 affects the hair defects, we use alopecia and excoriation mice, a new mouse mutation in this gene, as our research model. This mutation exhibits progressive hair loss, from head to the whole back, and followed by hair regrowth. We test that Gsdma3 is expressed in matrix, inner root sheath, and hair shaft. Ultrastructural and histological analyses show abnormal hair structures and reduced hair keratins in AE mice. The loss of interlocking structures and abnormal constitutive protein indicate defects in anchoring hair shaft in the hair follicle and resisting external forces. Molecular analysis of Gsdma3 deficiency and overexpression shows an Msx2/Foxn1/acidic hair keratin genetic pathway is involved. Thus, Gsdma3 is necessary for normal hair follicle differentiation.
Copyright © 2010. Published by Elsevier Inc.
Similar articles
-
A new Gsdma3 mutation affecting anagen phase of first hair cycle.Biochem Biophys Res Commun. 2007 Aug 10;359(4):902-7. doi: 10.1016/j.bbrc.2007.05.209. Epub 2007 Jun 8. Biochem Biophys Res Commun. 2007. PMID: 17572385
-
Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia.Differentiation. 2004 Oct;72(8):396-409. doi: 10.1111/j.1432-0436.2004.07208006.x. Differentiation. 2004. PMID: 15606499
-
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation.Dev Biol. 2009 Feb 15;326(2):420-30. doi: 10.1016/j.ydbio.2008.11.021. Epub 2008 Dec 7. Dev Biol. 2009. PMID: 19103190 Free PMC article.
-
Learning from nudity: lessons from the nude phenotype.Exp Dermatol. 2005 Nov;14(11):797-810. doi: 10.1111/j.1600-0625.2005.00362.x. Exp Dermatol. 2005. PMID: 16232301 Review.
-
Beauty is skin deep: the fascinating biology of the epidermis and its appendages.Harvey Lect. 1998-1999;94:47-77. Harvey Lect. 1998. PMID: 11070952 Review.
Cited by
-
Gsdma3 is required for mammary gland development in mice.Histochem Cell Biol. 2017 May;147(5):575-583. doi: 10.1007/s00418-017-1542-z. Epub 2017 Feb 6. Histochem Cell Biol. 2017. PMID: 28168650
-
Chemical Modulation of Gasdermin-Mediated Pyroptosis and Therapeutic Potential.J Mol Biol. 2022 Feb 28;434(4):167183. doi: 10.1016/j.jmb.2021.167183. Epub 2021 Aug 3. J Mol Biol. 2022. PMID: 34358546 Free PMC article. Review.
-
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective.Signal Transduct Target Ther. 2024 Sep 20;9(1):245. doi: 10.1038/s41392-024-01958-2. Signal Transduct Target Ther. 2024. PMID: 39300122 Free PMC article. Review.
-
Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome.G3 (Bethesda). 2013 Oct 3;3(10):1843-50. doi: 10.1534/g3.113.007393. G3 (Bethesda). 2013. PMID: 23979942 Free PMC article.
-
Channelling inflammation: gasdermins in physiology and disease.Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z. Epub 2021 Mar 10. Nat Rev Drug Discov. 2021. PMID: 33692549 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
