Hypoalgesia in mice lacking aquaporin-4 water channels
- PMID: 20851747
- DOI: 10.1016/j.brainresbull.2010.08.015
Hypoalgesia in mice lacking aquaporin-4 water channels
Abstract
Previous studies have demonstrated the involvement of astrocytes in the modulation of pain. The water channel aquaporin-4, which is expressed in astrocytes but not neurons, has also been demonstrated to function in sensory processing, including hearing, vision, and olfaction. In the present study, we investigated a possible role of aquaporin-4 in the processing of nociception by measuring behavioral responses to noxious stimulation in aquaporin-4 knockout mice. Pain thresholds were increased in knockout mice, when compared to wild-type mice, with thermal and chemical stimulation but not mechanical stimulation. Aquaporin-4 knockout mice presented normal locomotor activity and basal skin temperature. Likewise, the electrophysiological recordings showed a significant decrease in the number of dorsal horn neurons sensitive to noxious thermal stimuli in aquaporin-4 knockout mice. Moreover, latencies to thermal stimuli were significantly prolonged in a subset of dorsal horn wide-dynamic-range neurons. Taken together, these results suggest that aquaporin-4 plays a role in the processing of nociception.
2010 Elsevier Inc. All rights reserved.
Similar articles
-
Impaired pain sensation in mice lacking Aquaporin-1 water channels.Biochem Biophys Res Commun. 2006 Mar 24;341(4):1022-8. doi: 10.1016/j.bbrc.2006.01.062. Epub 2006 Jan 25. Biochem Biophys Res Commun. 2006. PMID: 16476579
-
Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel.Mol Cell Neurosci. 2001 Aug;18(2):235-45. doi: 10.1006/mcne.2001.1013. Mol Cell Neurosci. 2001. PMID: 11520183
-
Enhanced thermal avoidance in mice lacking the ATP receptor P2X3.Pain. 2005 Jul;116(1-2):96-108. doi: 10.1016/j.pain.2005.03.030. Pain. 2005. PMID: 15927378
-
Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat.Exp Neurol. 1997 Oct;147(2):428-36. doi: 10.1006/exnr.1997.6555. Exp Neurol. 1997. PMID: 9344567
-
Measuring pain in the (knockout) mouse: big challenges in a small mammal.Behav Brain Res. 2001 Nov 1;125(1-2):65-73. doi: 10.1016/s0166-4328(01)00281-9. Behav Brain Res. 2001. PMID: 11682095 Review.
Cited by
-
Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain.ASN Neuro. 2015 Oct 21;7(5):1759091415605486. doi: 10.1177/1759091415605486. Print 2015 Sep-Oct. ASN Neuro. 2015. PMID: 26489685 Free PMC article.
-
Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1.J Neuroinflammation. 2011 Apr 13;8:33. doi: 10.1186/1742-2094-8-33. J Neuroinflammation. 2011. PMID: 21489258 Free PMC article.
-
Extracellular signal-regulated protein kinase activation in spinal cord contributes to pain hypersensitivity in a mouse model of type 2 diabetes.Neurosci Bull. 2014 Feb;30(1):53-66. doi: 10.1007/s12264-013-1387-y. Epub 2013 Nov 5. Neurosci Bull. 2014. PMID: 24194231 Free PMC article.
-
Inhibition of aquaporin-4 and its subcellular localization attenuates below-level central neuropathic pain by regulating astrocyte activation in a rat spinal cord injury model.Neurotherapeutics. 2024 Mar;21(2):e00306. doi: 10.1016/j.neurot.2023.e00306. Epub 2023 Dec 19. Neurotherapeutics. 2024. PMID: 38237380 Free PMC article.
-
Expression and function of aquaporins in peripheral nervous system.Acta Pharmacol Sin. 2011 Jun;32(6):711-5. doi: 10.1038/aps.2011.63. Epub 2011 May 23. Acta Pharmacol Sin. 2011. PMID: 21602841 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
