Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma
- PMID: 20851644
- DOI: 10.1016/j.jamcollsurg.2010.06.020
Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma
Abstract
Background: Genotype B and C are the predominant hepatitis B virus (HBV) strains in Taiwan. We aimed to investigate the role of genotype in HBV-related hepatocellular carcinoma (HCC) after resection.
Study design: From October 2005 to November 2008, 64 patients who underwent liver resection for HBV-related HCC were enrolled. HBV genotypes were determined by molecular method. Patient characteristics, biochemical, tumor, and viral factors were evaluated for their prognostic significance.
Results: During a mean follow-up of 26.6 ± 13.2 months, patients infected with genotype C had higher HBV viral load (p = 0.007) and worse disease-free survival rate (p = 0.028) than patients with genotype B. By univariate analysis, genotype C, alanine transaminase >50 U/L, tumor size ≥5 cm, and microvascular invasion were associated with tumor recurrence. Further multivariate analysis demonstrated genotype C remained a significant risk factor (p = 0.034).
Conclusions: Genotype C is a strong risk factor for HCC recurrence after resection. More intensive monitoring for recurrence should be considered in patients with genotype C.
Copyright © 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
Similar articles
-
High viral load is associated with poor overall and recurrence-free survival of hepatitis B virus-related hepatocellular carcinoma after curative resection: a prospective cohort study.Eur J Surg Oncol. 2012 Aug;38(8):683-91. doi: 10.1016/j.ejso.2012.04.010. Epub 2012 May 22. Eur J Surg Oncol. 2012. PMID: 22621971
-
Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area.Carcinogenesis. 2008 Sep;29(9):1685-91. doi: 10.1093/carcin/bgm301. Epub 2008 Jan 12. Carcinogenesis. 2008. PMID: 18192693
-
Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection.Am J Gastroenterol. 2008 Jul;103(7):1663-73. doi: 10.1111/j.1572-0241.2008.01872.x. Epub 2008 Jul 4. Am J Gastroenterol. 2008. PMID: 18616655
-
[Aberration in HBV genome and hepatocellular carcinoma].Nihon Rinsho. 2004 Aug;62 Suppl 8:372-6. Nihon Rinsho. 2004. PMID: 15453349 Review. Japanese. No abstract available.
-
[Features of hepatitis B virus-related hepatocellular carcinoma].Nihon Rinsho. 2001 Oct;59 Suppl 6:435-9. Nihon Rinsho. 2001. PMID: 11761988 Review. Japanese. No abstract available.
Cited by
-
The contribution of serum hepatitis B virus load in the carcinogenesis and prognosis of hepatocellular carcinoma: evidence from two meta-analyses.Oncotarget. 2016 Aug 2;7(31):49299-49309. doi: 10.18632/oncotarget.10335. Oncotarget. 2016. PMID: 27384478 Free PMC article.
-
HBV mutations in EnhII/BCP/PC region contribute to the prognosis of hepatocellular carcinoma.Cancer Med. 2019 Jun;8(6):3086-3093. doi: 10.1002/cam4.2169. Epub 2019 Apr 29. Cancer Med. 2019. PMID: 31033235 Free PMC article.
-
Landscape of oncoviral genotype and co-infection via human papilloma and hepatitis B viral tumor in situ profiling.iScience. 2021 Mar 26;24(4):102368. doi: 10.1016/j.isci.2021.102368. eCollection 2021 Apr 23. iScience. 2021. PMID: 33889830 Free PMC article.
-
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma.World J Gastroenterol. 2011 Oct 14;17(38):4258-70. doi: 10.3748/wjg.v17.i38.4258. World J Gastroenterol. 2011. PMID: 22090781 Free PMC article. Review.
-
The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data.PLoS One. 2015 May 5;10(5):e0125555. doi: 10.1371/journal.pone.0125555. eCollection 2015. PLoS One. 2015. PMID: 25942596 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
