Review
doi: 10.1038/nrm2974.
Epub 2010 Sep 15.
Pathways of mammalian replication fork restart
Affiliations
- PMID: 20842177
- DOI: 10.1038/nrm2974
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Review
Pathways of mammalian replication fork restart
Nat Rev Mol Cell Biol.
2010 Oct.
Abstract
Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.
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