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Review
. 2010 Sep;16(9):1583-97.
doi: 10.1002/ibd.21282.

Toll-like receptors in inflammatory bowel diseases: a decade later

Elke Cario  1
Affiliations
Free PMC article
Review

Toll-like receptors in inflammatory bowel diseases: a decade later

Elke Cario. Inflamm Bowel Dis. 2010 Sep.
Free PMC article

Abstract

Differential alteration of Toll-like receptor (TLR) expression in inflammatory bowel disease (IBD) was first described 10 years ago. Since then, studies from many groups have led to the current concept that TLRs represent key mediators of innate host defense in the intestine, involved in maintaining mucosal as well as commensal homeostasis. Recent findings in diverse murine models of colitis have helped to reveal the mechanistic importance of TLR dysfunction in IBD pathogenesis. It has become evident that environment, genetics, and host immunity form a multidimensional and highly interactive regulatory triad that controls TLR function in the intestinal mucosa. Imbalanced relationships within this triad may promote aberrant TLR signaling, critically contributing to acute and chronic intestinal inflammatory processes in IBD colitis and associated cancer.

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Figures

FIGURE 1
FIGURE 1
Environment, genetics, and host immunity form a multidimensional and highly interactive regulatory triad that controls TLR function in the intestinal mucosa. Multiple factors may positively or negatively regulate TLR signaling.
See this image and copyright information in PMC

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