doi: 10.1089/aid.1990.6.1221.
The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
Affiliations
- PMID: 2078405
- DOI: 10.1089/aid.1990.6.1221
Item in Clipboard
The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus
AIDS Res Hum Retroviruses.
1990 Nov.
Abstract
The complete nucleotide sequence of an infectious clone of simian immunodeficiency virus of macaques, SIVmac239, has been determined. Virus produced from this molecular clone causes AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. The proviral genome including both long terminal repeats is 10,279 base pairs in length and contains open reading frames for gag, pol, vif, vpr, vpx, tat, rev, and env. The nef gene contains an in-frame premature stop after the 92nd codon. At the nucleotide level, SIVmac239 is closely related to SIVmac251 (98%) and SIVmac142 (96%). It will not be possible to test which features of the viral sequence are critical molecular determinants for the pathogenesis of AIDS.
Similar articles
-
Molecular and biological characterization of simian immunodeficiency virus macaque strain 32H proviral clones containing nef size variants.J Gen Virol. 1994 Mar;75 ( Pt 3):529-43. doi: 10.1099/0022-1317-75-3-529. J Gen Virol. 1994. PMID: 8126450
-
A cell-free stock of simian-human immunodeficiency virus that causes AIDS in pig-tailed macaques has a limited number of amino acid substitutions in both SIVmac and HIV-1 regions of the genome and has offered cytotropism.Virology. 1997 May 12;231(2):313-21. doi: 10.1006/viro.1997.8534. Virology. 1997. PMID: 9168893
-
Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques.Virology. 1998 Sep 1;248(2):275-83. doi: 10.1006/viro.1998.9300. Virology. 1998. PMID: 9721236
-
Derivation and biological characterization of a molecular clone of SHIV(KU-2) that causes AIDS, neurological disease, and renal disease in rhesus macaques.Virology. 1999 Aug 1;260(2):295-307. doi: 10.1006/viro.1999.9812. Virology. 1999. PMID: 10417264
-
Genetic and biological comparisons of pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus (SIVmac).AIDS Res Hum Retroviruses. 1992 Mar;8(3):395-402. doi: 10.1089/aid.1992.8.395. AIDS Res Hum Retroviruses. 1992. PMID: 1571198 Review.
Cited by
-
Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag.Front Microbiol. 2020 Jun 11;11:1230. doi: 10.3389/fmicb.2020.01230. eCollection 2020. Front Microbiol. 2020. PMID: 32595622 Free PMC article.
-
Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques.J Virol. 2001 Sep;75(17):8137-46. doi: 10.1128/jvi.75.17.8137-8146.2001. J Virol. 2001. PMID: 11483759 Free PMC article.
-
Mechanisms for adaptation of simian immunodeficiency virus to replication in alveolar macrophages.J Virol. 2000 Nov;74(22):10852-9. doi: 10.1128/jvi.74.22.10852-10859.2000. J Virol. 2000. PMID: 11044136 Free PMC article.
-
Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system.J Virol. 2003 Feb;77(4):2400-9. doi: 10.1128/jvi.77.4.2400-2409.2003. J Virol. 2003. PMID: 12551977 Free PMC article.
-
Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDS.J Virol. 1993 Nov;67(11):6522-34. doi: 10.1128/JVI.67.11.6522-6534.1993. J Virol. 1993. PMID: 8411355 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
