Review
doi: 10.1016/0968-0004(90)90303-s.
The retention signal for soluble proteins of the endoplasmic reticulum
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- PMID: 2077689
- DOI: 10.1016/0968-0004(90)90303-s
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Review
The retention signal for soluble proteins of the endoplasmic reticulum
Trends Biochem Sci.
1990 Dec.
Abstract
The lumen of the endoplasmic reticulum (ER) contains a number of soluble proteins, many of which help the maturation of newly synthesized secretory proteins. Retention of these resident proteins in the ER is dependent on a carboxy-terminal signal, which in animal cells is usually Lys-Asp-Glu-Leu (KDEL). This signal is thought to be recognized by a membrane-bound receptor that continually retrieves the proteins from a later compartment of the secretory pathway and returns them to the ER.
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