Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
- PMID: 20727418
- DOI: 10.1016/j.drudis.2010.08.007
Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
Abstract
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to form a fine emulsion (micro/nano) with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This article presents an exhaustive account of various literature reports on diverse types of self-emulsifying formulations with emphasis on their formulation, characterization and in vitro analysis, with examples of currently marketed preparations.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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